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This should be pretty self-explanatory. I've listed all of the areas, along with anything of interest that you can find in them. The area levels can be found at the end of the listing.
Notes:
-Categories are only used if there was information to be placed under them; the Blood Moor has no "waypoint" category because it doesn't have a waypoint, not because I didn't want to include it.
-The Super-Uniques are categorized by the appearance, movement, and attacks of the monster that they are, not by the actual class. For example, Rakinishu is a Carver Super-Unique, but I labeled him "Fallen-class" (my apologies if I didn't phrase it well).
Act 1
Town: Rogue Encampment (leads into the Blood Moor)
NPCs (in town):
Charsi sells items, repairs equipment, and will imbue one non-magical item once you bring her the Horadric Malus (quest five in the Act 1).
Warriv will take you to Lut Gholein (the Act 2 town) once you defeat Andariel (the boss of Act 1, located in Catacombs level four).
Gheed will sell you useless items and allow you to gamble.
Akara will heal you when you talk to her. She will also sell you wands, staves, scepters, and the like. She will “translate” the Scroll of Inifuss, allowing you to access Tristram.
Kashya will sell you Rogue Mercenaries. These use a bow, and come with either Fire Arrow or Cold Arrow. They cannot equip crossbows.
NPCs (found elsewhere):
Flavie is found guarding the entrance to the Cold Plains. She has no purpose.
Deckard Cain is found in the center of Tristram, trapped in a cage. He will identify every item in your inventory when you talk to him, but you must free him first (you can still use him if you are in the game of someone that has freed him, but there will be a fee of 100g per item). He will appear in town, and is usually near your stash. Cain will be with you in every act, as well.
Areas:
Blood Moor (leads into the Cold Plains)
Areas of interest: The Den of Evil.
Den of Evil
Levels: One.
Super Unique monsters or Bosses: Corpsefire, a Zombie-class Super Unique. His mods in Normal are “Undead, Spectral Hit”.
Golden chests: One.
Cold Plains (leads into the Burial Grounds and the Stony Field)
Areas of interest: The Cave.
Waypoint: Yes.
Super Unique monsters or Bosses: Bishibosh, a Shaman-class Super Unique. His mods in Normal are “Demon, Magic Resistant, Fire Enchanted, Immune to Fire”.
The Cave
Levels: Two.
Super Unique monsters or Bosses: Coldcrow, a Rogue Archer-class Super Unique. Her mods in Normal are “Demon, Cold Enchanted”.
Golden chests: One, located on level two.
Burial Grounds
Areas of interest: The Crypt and the Mausoleum.
Super Unique monsters or Bosses: Blood Raven, a Rogue Archer-class mini-Boss. She is a Demon.
Crypt
Levels: One.
Super Unique monsters or Bosses: Bonebreaker, a Skeleton-class Super Unique. His mods in Normal are “Undead, Extra Strong, Magic Resistant”.
Golden chests: One.
Mausoleum
Levels: One.
Golden chests: One.
Stony Field
Areas of interest: The Cairn Stones (used to access Tristram), the Moldy Tome (gives details on the Forgotten Tower), and the Underground Passage.
Waypoint: Yes.
Super Unique monsters or Bosses: Rakinishu, a Fallen-class Super Unique located in the center of the Cairn Stones. His mods in Normal are “Demon, Extra Fast, Lightning Enchanted”.
Tristram
Areas of interest: Cain’s Gibbet (Deckard Cain is inside of this cage) and Wirt’s Body (you can obtain Wirt’s Leg by clicking on this).
Super Unique monsters or Bosses: Griswold, a mini-Boss. His mods in Normal are “Undead, Cursed”.
Notes: This area will have three random Champion/Fanatic/Berserker/Ghostly/Possessed monsters of either the Shaman, Skeleton, Skeleton Archer, or Clan (the goat-men) species somewhere near Cain’s Gibbet.
Underground Passage
Levels: 2
Areas of interest: Stairway to the Dark Wood.
Golden chests: One, located on level two.
Dark Wood (leads into the Black Marsh)
Areas of interest: The Tree of Inifuss (when you click on this, the Scroll of Inifuss-used to access Tristram through the Cairn Stones-appears on the ground).
Waypoint: Yes.
Super Unique monsters or Bosses: Treehead Woodfist, a Super-Unique Gargantuan Beast-class located next to the Tree of Inifuss. His mods in Normal are “Extra Strong, Extra Fast”.
Black Marsh (leads into the Tamoe Highland)
Areas of interest: The Forgotten Tower.
Waypoint: Yes.
Forgotten Tower
Levels: Five.
Super Unique monsters or Bosses: The Countess, a Rogue-class Super Unique located on level five, in the room opposite the stairs. Her mods in Normal are “Demon, Fire Enchanted”.
Notes: There will generally be one Unique monster on each floor. The chest in the Countess’ room acts like a golden chest, but it will only open the first time you kill her.
Notes: The Countess will always drop a rune or two when she dies.
The Hole
Levels: Two.
Golden chests: One, located on level two.
Tamoe Highland (leads into the Monastary Gate)
Areas of interest: The Pit.
The Pit
Levels: Two.
Golden chests: One, located on level two.
Monastary Gate (leads into the Outer Cloister)
Notes: This is a very small area, located just before the Outer Cloister.
Outer Cloister (leads into the Barracks)
Waypoint: Yes.
Barracks
Areas of interest: Stairway to the Jail and the Horadric Malus.
Super Unique monsters or Bosses: The Smith, a Smith-class Super-Unique. His mods in Normal are “Demon, Extra Strong”.
Jail
Levels: Three.
Areas of interest: Stairway to the Inner Cloister.
Waypoint: Yes; located on level one.
Super Unique monsters or Bosses: Pitspawn Fouldog, a Super Unique Mishappen-class (the bulls that launch lightning balls at you) located on level two. His mods in Normal are “Demon, Cursed, Cold Enchanted”.
Inner Cloister
Waypoint: Yes.
Cathedral
Areas of interest: Stairway to the Catacombs.
Super Unique monsters or Bosses: Bone Ash, a Skeleton Mage-class Super-Unique located near the altar. His mods in Normal are “Undead, Magic Resistant, Extra Strong, Cold Enchanted, Immune to Cold”.
Catacombs
Levels: Four.
Waypoint: Yes; located on level two.
Super Unique monsters or Bosses: Andariel, the act boss, is located on level four. She is a demon (as are all act bosses). Her attacks are:
1) A 160-degree or so arc of poison spreading in front of her.
2) A poison bolt.
3) A physical attack.
Notes: Andariel has a –50% resistance to fire.
Special area: The Secret Cow Level (also known as the Moo Moo Farm).
The cow level can only be activated once you have completed the difficulty in which you wish to open it (complete Normal, and you can open it in Normal). It consists of a large, Blood Moor-esque area full of bipedal cows wielding halberds. These are an excellent source of experience, gold, and items. The cows are, however, quite strong (namely in Nightmare and Hell difficulties), and are always found in herds. Classes such as the Furyzon (main attack being Lightning Fury) are excellent at bringing the herds down, but characters with single-enemy attacks might have difficulty. You can always leech off of other players, but this is looked down upon. There will always be a Super-Unique in this area, the Cow King. He can be found in the large, fort-like enclosure somewhere within this level. His mods in Normal are "Lightning Enchanted, Immune to Lightning. When you or someone in your party kills the Cow King, you will not be able to open the portal to the cow level again. To open the portal, transmute a Tome of Town Portal and Wirt's Leg (found in Tristram by clicking on Wirt's Body) in the Horadric Cube. A red portal will open.
Comment from staticj: It doesn't matter if someone in your party kills the king as long as you dont hit or get hit by him or his lightning. If you hit him or he hits you and he's killed THEN you can't make the cow level, but if you dont hit him nor he hits you then you can still make the level if he's killed, even by party members.
Town: Lut Gholein (leads into the Rocky Wastes, the Harem [through the palace], and the Sewers [through a trap-door near Greiz])
NPCs (in town):
Fara will heal you when you talk to her, and will repair/sell items.
Atma gives you the first quest.
Jerhyn lives in the palace-you need to talk with him and Meshif to enter the next act.
Lysander sells potions and keys.
Geglash has no purpose.
Drognan sells you staves, wands, scepters, identification and town portal items, and some potions, along with selected weapons and shields.
Greiz will sell you Desert Guardsmen mercenaries. You can equip them with spear and polearm-class weapons. These are unique in that they have auras. The aura is different if you purchase the mercenary in Nightmare.
Combat Mercenary: Prayer in Normal, Thorns in Nightmare.
Offensive Mercenary: Blessed Aim in Normal, Might in Nightmare.
Defensive Mercenary: Defiance in Normal, Holy Freeze in Nightmare.
These are, in general, the preferred mercenary of the D2 community. They make wonderful tanks, and the auras can add to your damage, attack rating, and so on. The Holy Freeze mercenary in particular is prized for his ability to drastically slow every monster in a ~2 screen radius (when the aura is at level 20). He can also dish out a decent amount of cold damage, useful when you cannot damage a monster due to immunity.
Elzix allows you to gamble, and will sell weapons and armor.
Kaelan guards the palace, and prevents you from entering it until you complete the Claw Viper quest.
Meshif is will take you into the next act once you have defeated Duriel.
Deckard Cain.
Warriv has no purpose, although you can return to act one by talking to him (the waypoint is more convenient).
NPCs (found elsewhere):
Tyrael is located in Tal Rasha's Chamber, and will open a town portal once you talk to him.
Areas:
Sewers
Levels: Three.
Waypoint: Yes, located on level two.
Super-Unique or Boss: Radament, an Mummy-class mini-Boss located on level three. His mods in Normal are "Undead, Extra Fast".
Notes: The chest near Radament contains the Horadric Scroll.
Rocky Waste (leads into the Dry Hills)
Areas of interest: The Stony Tomb.
Stony Tomb
Levels: Two.
Super-Unique or Boss: Creeping Feature, a Decayed-class Super-Unique. His mods in Normal are "Undead, Extra Strong, Cold Enchanted".
Golden chests: One, located on level two.
Dry Hills (leads into the Far Oasis)
Areas of interest: The Halls of the Dead.
Waypoint: Yes.
Halls of the Dead
Levels: Three.
Waypoint: Yes; located on level two.
Super-Unique or Boss: Bloodwitch the Wild, a Saber Cat-class Super Unique. Her mods in Normal are "Extra Strong, Cursed".
Notes: The chest near Bloodwitch contains the Horadric Cube.
Far Oasis (leads into the Lost City)
Areas of interest: The Maggot Lair.
Waypoint: Yes.
Super-Unique or Boss: Beetleburst, a Scarab-class Super-Unique. His mods in Normal are "Magic Resistant".
Maggot Lair
Levels: Three.
Super-Unique or Boss: Coldworm the Burrower, a mini-boss located on level three. Her mods in Normal are "Cold Enchanted, Magic Resistant, Immune to Cold".
Notes: The chest near Coldworm contains the staff piece of the Horadric Staff.
Lost City (leads into the Valley of the Snakes)
Areas of interest: The Ancient Tunnels.
Waypoint: Yes.
Super-Unique or Boss: Dark Elder, a Zombie-class Super-Unique. His mods in Normal are "Undead, Extra Fast, Magic Resistant".
Ancient Tunnels
Golden chests: One.
Valley of the Snakes
Areas of interest: The Claw Viper Temple.
Notes: The Valley of the Snakes is a relatively small area that houses the Claw Viper Temple. This is its only purpose.
Claw Viper Temple
Levels: Two.
Super-Unique or Boss: Fangskin, a Claw Viper-class Super-Unique located on level two. His mods in Normal are "Lightning Enchanted, Extra Fast".
Notes: The Altar near Fangskin contains the amulet piece of the Horadric Staff.
Harem
Levels: Two.
Areas of interest: Stairway to the Palace Cellar on level two.
Palace Cellar
Levels: Three.
Areas of interest: The Portal on level three.
Waypoint: Yes; located on level one.
Portal
Notes: Takes you to the Arcane Sanctuary.
Arcane Sanctuary
Areas of interest: Horazon's Journal (gives you the symbol of Tal Rasha's Tomb (C), and opens a portal to the Canyon of the Magi).
Waypoint: Yes.
Super-Unique or Boss: The Summoner, a mini-boss. He has no mods, and uses the Sorceress' Glacial Spike and Firewall.
Canyon of the Magi
Areas of interest: Tal Rasha's Tomb (A), Tal Rasha's Tomb (B), and Tal Rasha's Tomb (C).
Waypoint: Yes.
Tal Rasha's Tomb (A)
Golden chests: One.
Notes: There are seven Tombs in the Canyon of the Magi. One of these is the true Tomb, one has Ancient Kaa the Soulless[/COLOR] and a golden chest, and the other five only have monsters and a golden chest. (A) is the title for the five false Tombs, (B) contains Ancient Kaa the Soulless, and (C) is the true Tomb.
Tal Rasha's Tomb (B)
Super-Unique or Boss: Ancient Kaa the Soulless, a Mummy-class Super-Unique. His mods in Normal are "Undead, Mana Burn, extra Strong, Lightning Enchanted".
Golden chests: One.
Notes: Ancient Kaa the Soulless isn't known by many people, but he can become very powerful in Hell difficulty. I've seen him with Multi-Shot, among other mods. Multi-Shot and Lightning Enchanted make a deadly combination-this will cause Ancient Kaa to fire a nova of high-powered Charged Bolts when hit.
Tal Rasha's Tomb (C)
Areas of interest: The Orifice (you must place the Horadric Staff into this to unlock Tal Rasha's Chamber) and Tal Rasha's Chamber.
Tal Rasha's Chamber
Areas of interest: Tyrael (he will open a town portal once you speak with him).
Super-Unique or Boss: Duriel, the act boss. He has the Paladin's Holy Freeze aura, as well as three attacks:
1) The Paladin's Charge, his most powerful attack.
2) The Barbarian's Stun.
3) An attack similar to the Paladin's Zeal-two quick blows.
Notes: "Cannot be Frozen" will not work against Duriel, as Holy Freeze relies on faith rather than the elements. However, Cold resistance and "Half Freeze Duration" items will help.
Meshif will take you back to act two, although the waypoint route is still faster.
Ormus will heal you when you talk to him, and will sell wands, staves, scepters, identify and town portal items, potions, swords, and helms.
Natalya is an Assassin with no purpose other than promoting the LoD expansion (well, this was before the expansion came out).
Hratli is the town blacksmith.
Alkor sells you useless potions and allows you to gamble. He will also make the potion of Ku'yleh (+20 HP), and allow you to use Lam Esen's Tome (+5 stat points).
Asheara sells some items, along with the Iron Wolf mercenaries. You can equip them with a one-handed sword and a shield. They come in three flavors, each with two attacks:
Fire: Fireball and Inferno
Cold: Glacial Spike and Frozen Armor
Lightning: Charged Bolt and Lightning Bolt
These are a waste of gold. They're useful for hitting the fast-moving Fetish-class enemies, though, so you can pick one up while you're in this act.
Deckard Cain.
Areas:
Spider Forest (leads into the Great Marsh)
Areas of interest: The Spider Cavern and the Arachnid Lair.
Waypoint: Yes.
Spider Cavern
Super-Unique or Boss: Sszark the Burning, a Spider-class Super-Unique. His mods in Normal are "Extra Strong, Cursed".
Notes: The chest near Sszark the Burning contains Khalim's Eye, a piece of Khalim's Will.
Arachnid Lair
Golden chests: One.
Great Marsh (leads into the Flayer Jungle)
Waypoint: Yes.
Golden chests: One.
Flayer Jungle (leads into Lower Kurast)
Areas of interest: The Flayer Dungeon, the Swampy Pit, and the Gidbinn (bring this to Ormus for a rare ring).
Waypoint: Yes.
Super-Unique or Boss: Stormtree, a Bramble Hulk-class (the large tree creatures that use Frenzy) Super-Unique. His mods in Normal are "Extra Fast, Lightning Enchanted".
Flayer Dungeon
Levels: Three.
Super-Unique or Boss:
-Ice Crawler, a Flayer-class Super-Unique located on level one. His mods in Normal are "Demon, Aura Enchanted".
-Witch Doctor Endugu, a Flayer Shaman-class Super-Unique located on level three. His mods in Normal are "Demon, Magic Resistant, Fire Enchanted, Immune to Fire".
Notes: The chest near Endugu contains Khalim's Brain, a piece of Khalim's Will.
Swampy Pit
Levels: Three.
Golden chests: One.
Lower Kurast (leads into the Kurast Bazaar)
Waypoint: Yes.
Kurast Bazaar (leads into Upper Kurast)
Areas of interest: The Sewers and the Tome Temples (these will have their own section at the end of act three).
Waypoint: Yes.
Sewers (not to be confused with the Sewers of Act 2)
Levels: Two.
Super-Unique or Boss: Icehawk Riftwing, a Bat-class Super-Unique located on level one. His mods in Normal are "Cold Enchanted, Teleportation".
Golden chests: One.
Notes:
-This area has four entrances; two in the Kurast Bazaar and two in Upper Kurast.
-The chest on level two contains Khalim's Heart, a piece of Khalim's Will.
Upper Kurast (leads into the Kurast Causeway)
Areas of interest: Tome Temples.
Waypoint: Yes.
Kurast Causeway (leads into the Travincal)
Areas of interest: Tome Temples.
Notes: This is a small area between Upper Kurast and the Travincal.
Travincal
Areas of interest: The Compelling Orb (destroy this with Khalim's Will to enter the Durance of Hate) and the Durance of Hate.
Waypoint: Yes.
Super-Unique or Boss:
-Toorc Icefist, a Council-class Super-Unique. His mods in Normal are "Demon, Cold Enchanted, Stone Skin".
-Ismail Vilehand, a Council-class Super Unique. His mods are "Demon, Extra Fast, Cursed".
-Geleb Flamefinger, a Council-class Super-Unique. His mods in Normal are "Demon, Extra Strong, Fire Enchanted".
Notes:
-The Council members will drop Khalim's Flail when defeated. Combine this with Khalim's Heart, Khalim's Brain, and Khalim's Eye to create Khalim's Will. Use Khalim's Will to smash the Compelling Orb, granting access to the Durance of Hate.
-If you do not have the Horadric Cube by the time you fight the Council, they will drop it.
Durance of Hate
Levels: Three.
Waypoint: Yes; located on level two.
Super-Unique or Boss:
-Bremm Sparkfist, a Council-class Super-Unique located on level three. His mods in Normal are "Demon, Aura Enchanted, Lightning Enchanted".
-Wyand Voidbringer, a Council-class Super-Unique located on level three. His mods in Normal are "Demon, Mana Burn, Teleportation".
-Maffer Dragonhand, a Council-class Super-Unique located on level three. His mods in Normal are "Demon, Extra Strong, Extra Fast".
-Mephisto, the act boss (located on level three). His attacks are:
1) The ice ball, his most powerful attack.
2) Blizzard.
3) Frost Nova.
4) Charged Bolt.
5) Lightning.
6) A poison cloud (this will surround him).
7) A physical attack.
Act 3 Special: Tome Temples
The "tome temples" are found scattered throughout the Kurast areas, and they are:
-Disused Fane
-Ruined Temple
-Forgotten Reliquary
-Forgotten Temple
-Disused Reliquary
-Ruined Fane
Every temple (other than the Ruined Temple) contains a Unique monster and several other monsters. The Ruined Temple, however, contains Lam Esen's Tome (bring this to Alkor to receive five stat points), and the Super Unique Rogue-class monster Battlemaid Sarina. Her mods in Normal are "Demon, Extra Fast, Spectral Hit".
Town: Pandemonium Fortress (leads into the Outer Steppes)
NPCs (in town):
Halbu is the town blacksmith.
Jamela will gamble, and sell you identify and town portal items, potions, keys, staves, scepters, wands, swords, helms, armor, shields, crossbows, and other mildly useful items.
Tyrael will open the portal to Act 5 once you have defeated Diablo.
Deckard Cain.
NPCs (elsewhere):
Hadriel guards the entrance to the small area between the River of Flame waypoint and the Chaos Sanctuary. It consists of several bridge-like structures floating on a river of lava. It begins behind Hadriel.
Areas:
The Outer Steppes (leads into the Plains of Despair)
Plains of Despair (leads into the City of the Damned)
Super-Unique or Boss: Izual, a Venom Lord-class mini-Boss. He has no mods in Normal. His attacks with the Sorceress' Frost Nova and a sword slash.
City of the Damned
Areas of interest: Stairway to the River of Flame.
Waypoint: Yes.
River of Flame (leads into the Chaos Sanctuary)
Areas of interest: The Hellforge (place Mephisto's Soulstone on this by clicking on the Hellforge while you have the Soulstone in your inventory. Then, click on it when you have the Hellforge Hammer equiped. The Soulstone will shatter, and several runes and/or gems will drop).
Waypoint: Yes.
Super-Unique or Boss: Hephasto the Armorer, a Smith-class Super-Unique. His mods in Normal are "Demon, Spectral Hit, Aura Enchanted".
Notes: Hephasto the Armorer drops the Hellforge Hammer. Also, the runes and gems that the Hellforge drops are of a very high quality (at least, some of them are). It will nearly always drop a perfect gem, that sort of thing. This is why the Hellforge drop is often exchanged for a "rush". The runes that the Hellforge can drop are:
Normal: El - Amn (#1 - #11)
Nightmare: Sol - Um (#12 - #22)
Hell: Hel - Gul (#15 - #25)
Chaos Sanctuary
Super-Unique or Boss:
-Grand Vizier of Chaos, a Storm Caster-class (the large ghost-like things that shoot red trails at you) Super-Unique. His mods in Normal are "Undead, Extra Strong, Fire Enchanted, Immune to Fire".
-Infector of Souls, a Venom Lord-class Super-unique. His mods in Normal are "Demon, Extra Fast, Spectral Hit".
-Lord De Seis, an Oblivion Knight-class Super Unique. His mods in Normal are "Undead, Extra Strong, Aura Enchanted".
-Diablo, the act boss. His attacks are:
1) The "lightning hose", his most powerful attack-he releases a large, lightning version of the Sorceress' Inferno attack, and locks onto you with it
2) A fire-based version of Frost Nova, with a much larger radius.
3) A larger version of the Druid's Firestorm attack.
4) A melee attack that chills you.
5) A physical attack.
Notes: The Super-Uniques are released by clicking on the seals. The seals on the western side of the Chaos Sanctuary release the Grand Vizier of Chaos. The seal to the north releases Lord De Seis. The seals to the east release the Infector of Souls. The last seal that you click on (I believe that the proper seal is the one above the Infector of Souls') releases Diablo (you'll know that he's free when the Chaos Sanctuary turns red and starts shaking).
Nihlathak will sell you poor items and gamble with you, until you rescue Anya.
Anya will take Nihlathak's role once you rescue her.
Qual-Kehk will sell you Barbarian mercenaries. These make excellent tanks, and can equip class-specific items (Barbarian helms and such). They use the Barbarian skills Bash and Stun, and can only equip two-handed swords.
Larzuk is the town blacksmith.
Malah will heal you when you talk to her, and sells throwing weapons, staves, scepters, knives, wands, identify and town portal items, potions, and so on.
Deckard Cain.
Areas:
Bloody Foothills (leads into the Frigid Highlands)
Super-Unique or Boss:
-Dac Farren, an Imp-class Super-Unique. His mods in Normal are "Cold Enchanted".
-Shenk the Overseer, an Overseer-class Super-Unique. His mods in Normal are "Extra Strong".
Notes: You must kill Shenk to complete quest one. Once he dies, everything around him will be bombarded with catapult-shots.
Frigid Highlands (leads into the Arreat Plateau)
Areas of interest: The Barbarian Pens and Abaddon.
Waypoint: Yes.
Super-Unique or Boss:
-Eldritch the Rectifier, an Enslaved-class Super-Unique. His mods in Normal are "Extra Fast".
-Sharptooth Slayer, an Overseer-class Super-Unique. His mods in Normal are "Extra Fast".
-Eyeback the Unleashed, a Mauler-class (the thorny things that hit you through ground-spikes) Super-Unique. His mods in Normal are "Extra Strong, Extra Fast".
Notes: You must open three Barbarian Pens to complete quest two.
Abaddon
Golden chests: One.
Arreat Plateau
Areas of interest: The Pit of Acheron and the Crystalline Passage.
Waypoint: Yes.
Super-Unique or Boss: Thresh Socket, a Crush Beast-class Super-Unique. His mods in Normal are "Cursed".
Pit of Acheron
Golden chests: One.
Crystalline Passage
Areas of interest: The Frozen River and the Glacial Trail.
Waypoint: Yes.
Super-Unique or Boss: Frozenstein, an Abominable-class Super-Unique. His mods in Normal are "Cold Enchanted, Mana Burn, Immune to Cold".
Notes: Frozenstein guards Anya (who is trapped in ice).
Nihlathak's Temple
Areas of interest: Stairway to the Halls of Anguish.
Super-Unique or Boss: Pindleskin, a Rot Walker-class Super-Unique. His mods in Normal are "Undead, Fire Enchanted".
Notes: Anya opens a portal to this area once she is freed. This portal will close once you activate the waypoint in the Halls of Pain.
The Halls
Levels: Three, although these are labeled (in order) Halls of Anguish, Halls of Pain, and Halls of Vaught.
Waypoint: One, located in the Halls of Pain.
Super-Unique or Boss: Nihlathak, a mini-boss. He is a Necromancer, and will use the Necromancer's Corpse Explosion and the Druid's Arctic Blast against you. He can also summon Ice Spawn minions, as well as turn them into Frenzied Ice Spawn (the suicidal version).
Notes: You must kill Nihlathak to complete Anya's quest (quest four).
Glacial Trail
Areas of interest: The Drifter Cavern and the Frozen Tundra.
Waypoint: Yes.
Super-Unique or Boss: Bonesaw Breaker, a Rot Walker-class Super-Unique. His mod in Normal are "Undead, Extra Strong, Magic Resistant".
Golden chests: One.
Drifter Cavern
Golden chests: One.
Frozen Tundra
Areas of interest: The Infernal Pit and the Ancients' Way.
Waypoint: Yes.
Infernal Pit
Golden chests: One.
Ancients' Way
Areas of interest: The Arreat Summit and the Icy Cellar.
Waypoint: Yes.
Icy Cellar
Super-Unique or Boss: Snapchip Shatter, a Frozen Horror-class Super-Unique. His mods in Normal are "Cursed, Cold Enchanted, Immune to Cold".
Golden chests: One.
Arreat Summit
Areas of interest: The Altar of the Heavens (click this to release the Ancients) and the Worldstone Keep.
Super-Unique or Boss: The Ancients, a group of three mini-bosses. They are Talic, Madawc, and Korlic. Each uses the Barbarian's skill tree; Talic uses Whirlwind, Madawc uses Shout and Double Throw, and Korlic uses Leap Attack.
Notes: You cannot leave the Arreat Summit (by way of town portal scrolls and such) while the Ancients are free without having them reset. This can be useful if they spawn with nasty mods in Nightmare or Hell.
Worldstone Keep
Levels: Three.
Areas of interest: Stairway to the Throne of Destruction on level three.
Waypoint: Yes; located on level two.
Throne of Destruction
Areas of interest: The Worldstone Chamber.
Super-Unique or Boss:
-Colenzo the Annihilator, a Shaman-class Super-Unique. His mods in Normal are "Demon, Fire Enchanted, Immune to Fire".
-Achmel the Cursed, an Unraveler-class Super-Unique. His mods in Normal are "Undead, Immune to Poison".
-Bartuc the Bloody, a Council-class Super-Unique. his mods in Normal are "Demon, Lightning Enchanted".
-Ventar the Unholy, a Venom Lord-class Super-Unique. His mods in Normal are "Demon, Extra Fast". -Lister the Tormentor, a Minion of Destruction-class Super-Unique. His mods in Normal are "Demon, Spectral Hit".
-Baal, the act boss. When you enter the Worldstone Chamber, he will summon several Festering Appendages (arms that come out of the ground and hit you-they aren't worth killing, as they don't do much damage). He will continue to do this for the duration of the fight. His attacks are:
1) An arrow of cold on the ground, similar to the Assassin's Wake of Fire trap but with cold instead of fire, and much larger (this attack will knock you back quite a bit, chill you, and do a good amount of damage).
2) An attack similar to Diablo's "lightning hose" (although this one is yellow and drains mana).
3) A nova similar to Diablo's "fire nova" (this version is yellow).
4) A physical attack.
5) This is not an attack, per-se, but Baal can clone himself. Baal has the ability to create an exact duplicate of himself that does the same amount of damage and such, but will not give you the quest, experience, or items when killed. This is how to tell them apart:
Baal
Demon
^ This is the clone. The words "Baal" and "Demon" are perfectly aligned.
Baal
_Demon
^ This is the true Baal. As you can see, "Demon" is slightly to the right of the B in "Baal".
Notes:
-Baal will release the five Super-Unique packs once the throne area is clear of monsters. They are released one-by-one, in the order given.
-Lister the Tormenter and his pack have the ability to knockback and stun on hit. They are the only monsters of their type in the game. When you kill Baal, a portal named "Destruction's End" will open. This will end the fifth act. You will now be able to access Nightmare (or if you were in Nightmare, Hell).
Thanks to:
Anthraquinone, dreadlord, Shade, Richard-gm39, Christmas, Pelion, psychotron, A_S_G and staticj for correcting several mistakes, adding information, and suggesting information that should be included.
Hopefully there won't be any more changes, so this should be the final version of the guide.