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Originally Posted by Jerkazoid
an eth rune will lower the def 12.5%, however it is unclear if this is based on base def only.. or final def.
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I did some testing with a hacked 6 eth phase blade with some mods to make a hit more visible (leech, poison, etc) on a Sorceress with 800 AR (2k with Enchant).
Against a paladin who did not use defiance and holy shield, I hit about once every three or four times. When he switched them on, I noticed my hits being spaced out more (even counting the blocked hits), but I was still hitting with some regularity.
I then went up against a barbarian. I used Enchant on accident, and he had shout on all the time (I think). I could still force a block about once every three swings (He turned green about once every 7 or 8 swings, I think).
Because of this, I am willing to tentatively say that Eth works on total defense. This experiment was not conducted with great care and accuracy, so don't blame me if your 6 Eth weapon fails to produce intended results :P. I may do more testing later, but I encourage to test on your own. Hope this helps.