Basically I had the idea to use WotB with the Thrive on Chaos rune while soloing bosses like Diablo or Azmodan.
Frenzy + WotB = lots of fury generated....shouldnt this allow me to remain in Berserker mode permanently until the boss die or I disengage?
I think this is a fairly known strategy at this point. What will REALLY make this work is using Into the Fray rune on Battle Rage, which has a chance to give you extra fury every time you crit.
Also mix it up with Sprint with the Run Like the Wind rune (turn it on and then run around the boss a bit, dropping a tornado or two on him), and also maybe Whirlwind. That way you get in even more hits, which gets more crits, which gets Into the Fray to proc more often, which both keeps WotB alive and lets you spam fury skills.
Personally I really like the 100% attack boost that WotB's Maniac rune gives, though. Popping 80k+ damage and just tearing elites and bosses in half before they even know what to do is just too amazing.
I would assume that Weapon Throw with Dread Bomb would be the best fury spender for WotB/Thrive on Chaos builds. Other skills that have synergy with this build would be Weapons Master passive (mighty weapon +3 fury/hit), the rune for Battle Rage mentioned above, and the passive skill Animosity (+10% fury generation +20 max fury). If soloing, the Templar has a skill that increases resource generation.
I don't think all of these skills necessarily have to be used together in order for this set up to work, but you'll definitely need more constant fury than what Frenzy alone can give you.