Update after Beating Inferno Act 2:
So I spent about 15 million to gear up my barb--not outrageous, but certainly a fair amount of gold and effort involved (no real money gold buying, thanks). Spending this much gold on some pretty decent items leaves you pretty much one viable build: the tank we all know and love.
That said, I'm a pretty reasonable tank--dying in Act 2 was very rare--but I can't kill worth a damn in 4-player games (with a 920 dps axe, for what it is worth). Would I like to try some of the other skills? I have tried them all. Dropping any of the defensive passives means quick and frequent deaths. Revenge is certainly a must. Ignoring Warcry (Impunity) is just silly. Adding any offensive skill at the expense of my current Ignore Pain, Leap, or Berserker Rage can be situationally useful, but that's, again, part of the problem.
Blzzard touts this wonderful systems that lets us respec at will, yet they make a system (Neph Valor) that gives us a HUGE disincentive for swapping skill situationally. Anyone who changes skills during a run is simply playing stupidly--especially with the premium on gear for barbs.
Now, perhaps if I were able (and willing to put the time in) to spend 40, 50, or more millions on gear I might be able to switch to a reliable offensive build. I don't expect to see that any time soon. Oddly enough I find a system that restricts most of its features to very, very late game play a bit less than optimal.