EP is pretty neat in that it's like an odd, chainable Corpse Explosion for non-Essence Burn runes. This build is of course best in later difficulties where monsters' health is high.
The rune choice for EP is also variable, depending on how fast things die and how good you are at using it. In practice Essense Burn or The Flesh Is Weak may be quicker depending on your situation. But without further ado
Get EP applied then mangle everything until it all dies. It's unknown whether Essence Burn is the best or not, we'll just have to wait until release.