Can it be done? Uber Izual and Uber Baal are Cold Immune... But their resistance is 110%, so it can be broken with Infinity! If you stat for max Cold Mastery, you can have their res at -100% just like with the rest of the Ubers.
Stopping their regen could be done with Open Wounds from a bow (for Meph at least, as your merc won't survive him). Bone Prison charges from Marrow Walk can be used to trap Izual and Duriel at least (maybe not Lilith or the 'big' Ubers). Your merc can have a Dream helm to cast Confuse on the minions for crowd control. The only real trouble seems to be that Lilith's chambers have Hell Witches that cast Blood Mana if you have more mana than life, so you cannot use ES (not that you'd have many points if you use Blizzard, as you should since it does more dmg and is easier to aim than Orb).
I'm curious if anyone's tried this and how they fared. Obviously you'd need +6 BO CtA, Fathom etc. I might soon have enough gear to try this, so now's the time to convince me not to. I've just always been frustrated with the fact that Sorcs own the rest of the game and yet get punched to death by such punk-*** low-lifes as the Ubers. It's time to show the bosses who's boss (lol that could be from a cheesy 80'ies flick), so, chime in gents.