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Depends what you're shooting, and how many of it you're shooting. Those little flayer bastards? Orb. Big packs of witches? Meteor. Goatmen? Fireball.
Meteor is for stuff you can generally count on to stay in one place. That's bosses and ranged attackers. Orb is for area attacking lots of little bastards / spread out enemies. Fireball is for killing tight little groups of mans. Immunities permitting, obviously.
The way I play it is that everything that isn't CI gets orbed.
Not always the best strategy but it works just fine.
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